Preheat your oven to 375 degrees Fahrenheit.
Sauté the diced onion and minced garlic in a pan until translucent; set aside to cool slightly.
Combine the milk and breadcrumbs in a small bowl and let soak for 5 minutes.
In a large mixing bowl, whisk the eggs until well combined.
Add the ground beef, sautéed onion and garlic mixture, and the breadcrumb panade to the bowl.
Mix all ingredients together gently using your hands until just combined, being careful not to overwork the meat.
Shape the mixture into a loaf and place it onto a lined baking sheet.
In a small bowl, whisk the ketchup and brown sugar together to create the glaze.
Brush the glaze generously over the top of the loaf.
Bake for 60 minutes or until the internal temperature reaches 160 degrees Fahrenheit.
Let the meatloaf rest for 10 minutes before slicing to retain its juices.